Gene information
Official symbol VWF
Official full name von Willebrand factor
Gene type protein-coding gene
Chromosome12p13.31
Previous symbolF8VWF
Gene familyReceptor ligands
Resources
Entrez Gene 7450
HGNC HGNC:12726
Ensembl ENSG00000110799
Vega OTTHUMG00000168265
UCSC uc001qnn.2
GO terms: 26 records
GO Description Category LogP Number of genes Detail
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0005178 integrin binding GO Molecular Functions -20.5409412 26 More
GO:0005198 structural molecule activity GO Molecular Functions -7.51921139 30 More
GO:0005201 extracellular matrix structural constituent GO Molecular Functions -12.8379048 20 More
GO:0005518 collagen binding GO Molecular Functions -7.71267127 10 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0030135 coated vesicle GO Cellular Components -4.65185370 14 More
GO:0030136 clathrin-coated vesicle GO Cellular Components -3.00394155 9 More
GO:0030168 platelet activation GO Biological Processes -17.9354931 20 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031091 platelet alpha granule GO Cellular Components -43.3287145 36 More
GO:0031093 platelet alpha granule lumen GO Cellular Components -40.0105787 31 More
GO:0031589 cell-substrate adhesion GO Biological Processes -10.7590108 32 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0047485 protein N-terminus binding GO Molecular Functions -1.43728137 4 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051087 chaperone binding GO Molecular Functions -6.81600949 11 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
KEGG pathways: 8 records
KEGG Description Category LogP Number of genes Detail
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04510 Focal adhesion KEGG Pathway -16.5268196 41 More
hsa04512 ECM-receptor interaction KEGG Pathway -16.8587083 28 More
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
hsa04611 Platelet activation KEGG Pathway -14.0379587 18 More
hsa04613 Neutrophil extracellular trap formation KEGG Pathway -12.8071279 20 More
hsa05165 Human papillomavirus infection KEGG Pathway -8.63301470 40 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
Drug-Gene interaction
view
Related drugs: 14 records
Drug name Interaction type Source PMID View
acetylcysteine NCI 15753537 view
caplacizumab inhibitor TdgClinicalTrialChemblInteractionsTTD view
egaptivon pegol TdgClinicalTrial view
heparin NCI 1400429 view
mitomycin NCI 2104558 view
o-chloroacetylcarbamoylfumagillol NCI 14505755 view
pentoxifylline NCI 1719289 view
phenylephrine NCI 16996954 view
prednisone NCI 3146197 view
ribavirin NCI 15644045 view
streptozocin NCI 164228853928783 view
thalidomide NCI 12871448 view
vincristine NCI 3875694 view
warfarin NCI 7626351 view
Related studies: 21 records
Molecular factor Omics type Application Objective MI type Reference
NM_000552.5:c.7682T>A genomics myocardial infarction[diagnosis] myocardial infarction Schneppenheim R et al. Blood. 2019
von Willebrand factor proteomics infarct-related artery patency[prognosis (good)] acute myocardial infarction Andreotti F et al. Thromb Haemost. 1992
von Willebrand factor proteomics thrombolytic agent[treatment (pharmacotherapy)] acute myocardial infarction Federici AB et al. Blood. 1992
von Willebrand factor proteomics death[prognosis (bad)] myocardial infarction Jansson JH et al. Br Heart J. 1991
von Willebrand factor proteomics recurrent myocardial infarction[prognosis (bad)] myocardial infarction Jansson JH et al. Br Heart J. 1991
von Willebrand factor proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Tousoulis D et al. Int J Cardiol. 1996
von Willebrand factor proteomics cardiovascular death[prognosis (bad)] acute myocardial infarction Jansson JH et al. Heart. 1998
von Willebrand factor proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Sakai H et al. Thromb Haemost. 2000
von Willebrand factor proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Matsukawa M et al. Am J Cardiol. 2007
von Willebrand factor proteomics thrombotic disorder[prognosis (bad)] acute ST elevation myocardial infarction Matsukawa M et al. Am J Cardiol. 2007
von Willebrand factor proteomics good predictor coronary slow flow phenomenon[prognosis (bad)] acute ST elevation myocardial infarction Zhou Q et al. Zhonghua Xin Xue Guan Bing Za Zhi. 2011
von Willebrand factor proteomics myocardial infarction[diagnosis] myocardial infarction Andersson HM et al. Blood. 2012
von Willebrand factor proteomics medium predictor no-reflow phenomenon[prognosis (bad)] acute ST elevation myocardial infarction Zhao B et al. Tex Heart Inst J. 2011
von Willebrand factor proteomics ST elevation myocardial infarction[diagnosis] ST elevation myocardial infarction Rutten B et al. Eur Heart J Acute Cardiovasc Care. 2015
von Willebrand factor proteomics excellent predictor ischemic cardiac events[prognosis (bad)] non-ST elevation myocardial infarction Men JL et al. Int Heart J. 2015
von Willebrand factor proteomics type 2 diabetes mellitus[prognosis (bad)] ST elevation myocardial infarction Sambola A et al. Int J Cardiol. 2017
von Willebrand factor proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Al-Masri AA et al. Int J Vasc Med. 2020
NM_000552.5:c.7729+252A>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Shalia K et al. Indian J Med Res. 2017
von Willebrand factor proteomics myocardial infarction[diagnosis] myocardial infarction Wennberg P et al. Thromb Res. 2012
von Willebrand factor proteomics contrast-induced acute kidney injury[prognosis (bad)] acute ST elevation myocardial infarction Guerchicoff A et al. Catheter Cardiovasc Interv. 2015
von Willebrand factor proteomics recurrent myocardial infarction[prognosis (bad)] myocardial infarction Wiman B et al. Arterioscler Thromb Vasc Biol. 2000
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